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ea0021oc3.6 | Young Endocrinologists prize session | SFEBES2009

Men1 gene replacement therapy using a modified adenoviral vector demonstrates reduced proliferation rates in pituitary tumours from mice deleted for a multiple endocrine neoplasia type 1 allelle

Javid Mahsa , Walls Gerard , Lemos Manuel , Jeyabalan Jeshmi , Bazan-Peregrino Miriam , Tyler Damian , Stuckey Daniel , Seymour Len , Thakker Rajesh

Multiple endocrine neoplasia type 1 (MEN1) is characterised by the combined occurrence of pituitary, pancreatic and parathyroid tumours. The MEN1 gene encodes a 610-amino acid tumour suppressor, menin, and MEN1-associated tumours show loss of heterozygosity. This indicates that replacement of the wild-type MEN1 gene may inhibit tumourigenesis. We have previously demonstrated that a recombinant adenoviral vector could be safely injected directly into pituit...

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Endocrine Abstracts

Men1 gene replacement therapy using a modified adenoviral vector demonstrates reduced proliferation rates in pituitary tumours from mice deleted for a multiple endocrine neoplasia type 1 allelle

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